Singles
2010 Knoxville Challenger
Champion	Kei Nishikori
Runner-up	Robert Kendrick
Score	6–1, 6–4

Taylor Dent was the defending champion, however he chose to not compete this year.
Kei Nishikori won this tournament. He defeated Robert Kendrick 6–1, 6–4 in the final.

Seeds

Draw

Finals

	Semifinals							Final
	LL	Fritz Wolmarans	4	4
	6	Robert Kendrick	6	6
								6	Robert Kendrick	1	4
								3	Kei Nishikori	6	6
	3	Kei Nishikori	6	7
	Q	Nicholas Monroe	1	64

Top half

	First round							Second round							Quarterfinals							Semifinals
	1	R Sweeting	4	4
		M Yani	6	6					M Yani	0	3
		R DeHeart	5	7	6				R DeHeart	6	6
	Q	L Gregorc	7	65	1											R DeHeart	4	2
	PR	A Delić	6	7											LL	F Wolmarans	6	6
		G Jones	4	5				PR	A Delić	1	2
	PR	C Guccione	4	4				LL	F Wolmarans	6	6
	LL	F Wolmarans	6	6																		LL	F Wolmarans	4	4
	4	P Luczak	3	4																		6	R Kendrick	6	6
		I van der Merwe	6	6					I van der Merwe	61	6	5
		R de Voest	65	7	7				R de Voest	7	1	7
	WC	R Williams	7	5	66											R de Voest	4	4
		R Klaasen	2	7	7										6	R Kendrick	6	6
		J Levine	6	64	67				R Klaasen	5	2
		A Kuznetsov	6	2	2			6	R Kendrick	7	6
	6	R Kendrick	4	6	6

Bottom half

	First round							Second round							Quarterfinals							Semifinals
	8	T Smyczek	2	66
		B Reynolds	6	7					B Reynolds	7	6
	Q	Y Bhambri	4	6	4				L Cook	65	3
		L Cook	6	4	6											B Reynolds	3	2
	Q	D Martin	7	6											3	K Nishikori	6	6
	WC	E Quigley	63	4				Q	D Martin	3	2
	WC	J-P Smith	4	1				3	K Nishikori	6	6
	3	K Nishikori	6	6																		3	K Nishikori	6	7
	7	C Ball	6	64	6																	Q	N Monroe	1	64
	WC	B Čonkić	3	7	1			7	C Ball	66	3
		K Kim	1	4				Q	N Monroe	7	6
	Q	N Monroe	6	6											Q	N Monroe	7	7
		M McClune	2	7	2											J Witten	66	64
		A Bogomolov Jr.	6	65	6				A Bogomolov Jr.	6	4	611
		J Witten	2	6	6				J Witten	2	6	7
	2	D Young	6	4	2

References

• Main Draw
• Qualifying Draw