Singles
2012 Uruguay Open
Champions	Horacio Zeballos
Runners-up	Julian Reister
Score	6–3, 6–2

Carlos Berlocq was the defending champion but decided not to participate.
Horacio Zeballos won the title, defeating Julian Reister 6–3, 6–2 in the final.

Seeds

Draw

Finals

	Semifinals							Final
	PR	Julian Reister	6	6
		Agustín Velotti	1	1
								PR	Julian Reister	3	2
								7	Horacio Zeballos	6	6
	7	Horacio Zeballos	6	6
	6	Adrian Ungur	1	3

Top half

	First round							Second round							Quarterfinals							Semifinals
	1	J Sousa	77
	Q	D Junqueira	61	r				1	J Sousa	63	1
		F Argüello	4	2				PR	J Reister	77	6
	PR	J Reister	6	6											PR	J Reister	6	6
	WC	M Djokovic	3	7	66										WC	M González	3	3
	WC	M González	6	5	78			WC	M González	77	6
		S Greul	6	4	6				S Greul	62	3
	5	G Pella	1	6	2																	PR	J Reister	6	6
	LL	A van der Duim	1	1																			A Velotti	1	1
		A Velotti	6	6					A Velotti	6	6
	Alt	B Westerhof	0	1				SE	D Schwartzman	1	2
	SE	D Schwartzman	6	6												A Velotti	6	1	77
		G Andreozzi	5	6	4											A Veić	4	6	62
	Q	Arthur De Greef	7	3	6			Q	A De Greef	3	2
		A Veić	6	6					A Veić	6	6
	8	T de Bakker	2	2

Bottom half

	First round							Second round							Quarterfinals							Semifinals
	7	H Zeballos	6	4	6
		G Elias	4	6	4			7	H Zeballos	77	6
		P Capdeville	7	6					P Capdeville	65	3
	Q	T Brkić	5	3											7	H Zeballos	6	6
		L Kirche	64	4												B Pašanski	3	3
		B Pašanski	77	6					B Pašanski	6	7
		F Bagnis	63	2				4	B Kavčič	3	5
	4	B Kavčič	77	6																		7	H Zeballos	6	6
	6	A Ungur	6	6																		6	A Ungur	1	3
		R Dutra da Silva	3	2				6	A Ungur	6	6
		P Červenák	7	6					P Červenák	3	4
	WC	A Behar	5	1											6	A Ungur	6	6
	Q	S Robert	6	77											WC	M Felder	2	3
		G Clezar	1	65				Q	S Robert	6	3	2
	WC	M Felder	1	6	6			WC	M Felder	2	6	6
	2	A Haider-Maurer	6	4	2

References

• Main Draw
• Qualifying Draw