Singles
2016 Cary Challenger
Champion	James McGee
Runner-up	Ernesto Escobedo
Score	1–6, 6–1, 6–4

Dennis Novikov was the defending champion but lost in the semifinals to James McGee.

McGee won the title after defeating Ernesto Escobedo 1–6, 6–1, 6–4 in the final.

Seeds

Draw

Finals

	Semifinals							Final
	1	Dennis Novikov	6	3	3
	Q	James McGee	3	6	6
								Q	James McGee	1	6	6
								8	Ernesto Escobedo	6	1	4
	8	Ernesto Escobedo	6	65	77
	2	Frances Tiafoe	3	77	62

Top half

	First round							Second round							Quarterfinals							Semifinals
	1	D Novikov	78	6
		M Lībietis	66	4				1	D Novikov	6	6
		B Klein	1	7	6				B Klein	4	4
		S Bangoura	6	5	2										1	D Novikov	6	2	6
		E Gómez	6	6											5	P Polansky	3	6	4
	WC	Nick Stachowiak	1	3					E Gómez	0	3
		M Krueger	3	2				5	P Polansky	6	6
	5	P Polansky	6	6																		1	D Novikov	6	3	3
	3	A Krajicek	64	5																		Q	J McGee	3	6	6
	WC	B Schnur	77	7				WC	B Schnur	77	6
		E Quigley	7	6					E Quigley	61	1
		R Quiroz	5	3											WC	B Schnur	2	4
	Q	J McGee	7	77											Q	J McGee	6	6
		E King	5	63				Q	J McGee	6	6
		N Scholtz	4	4				6	D King	1	3
	6	D King	6	6

Bottom half

	First round							Second round							Quarterfinals							Semifinals
	8	E Escobedo	6	6
	WC	Nicholas Horton	2	2				8	E Escobedo	6	5	6
		A El Mihdawy	2	65				WC	R Shane	3	7	1
	WC	R Shane	6	77											8	E Escobedo	3	6	6
		P Bester	7	6											4	S Kozlov	6	1	2
		N Meister	5	3					P Bester	4	1
	Q	Erik Crepaldi	6	4	2			4	S Kozlov	6	6
	4	S Kozlov	3	6	6																	8	E Escobedo	6	65	77
	7	M Arévalo	4	3																		2	F Tiafoe	3	77	62
		C Norrie	6	6					C Norrie	64	3
		T Sandgren	6	6					T Sandgren	77	6
	Q	M McDonald	4	3												T Sandgren	4	6	65
		T Paul	7	2	4										2	F Tiafoe	6	1	77
		M Mmoh	5	6	6				M Mmoh	7	4	4
	Q	Ryan Haviland	6	3	62			2	F Tiafoe	5	6	6
	2	F Tiafoe	3	6	77

References

• Main Draw
• Qualifying Draw