Singles
2016 Samarkand Challenger
Champion	Karen Khachanov
Runner-up	Rubén Ramírez Hidalgo
Score	6–1, 6–7(6–8), 6–1

Teymuraz Gabashvili was the defending champion, but chose not to defend his title.

Karen Khachanov won the title after defeating Rubén Ramírez Hidalgo 6–1, 6–7^(6–8), 6–1 in the final.

Seeds

Draw

Finals

	Semifinals							Final
	1	Karen Khachanov	6	0
		Agustín Velotti	2	0r
								1	Karen Khachanov	6	66	6
									Rubén Ramírez Hidalgo	1	78	1
		Rubén Ramírez Hidalgo	2	77	77
		Ramkumar Ramanathan	6	65	60

Top half

	First round							Second round							Quarterfinals							Semifinals
	1	K Khachanov	6	7
	Q	Francesco Vilardo	2	5				1	K Khachanov	6	6
		L Harris	7	3	6				L Harris	2	3
	Q	BT Botzer	5	6	0										1	K Khachanov	77	6
		B Trinker	1	0												I Ivashka	65	3
		I Ivashka	6	6					I Ivashka	4	78	6
		M Tepavac	6	6					M Tepavac	6	66	3
	8	E López Pérez	3	2																		1	K Khachanov	6	0
	4	J Samper-Montaña	6	6																			A Velotti	2	0r
	WC	Shonigmatjon Shofayziyev	3	1				4	J Samper-Montaña	6	4	0
		A Velotti	6	6					A Velotti	3	6	6
	WC	T Ismailov	4	1												A Velotti	6	5	6
	Q	M Elgin	5	4												FF Silva	3	7	4
		FF Silva	7	6					FF Silva	78	6
		A Metreveli	2	3				6	D Popko	66	1
	6	D Popko	6	6

Bottom half

	First round							Second round							Quarterfinals							Semifinals
	5	F Dustov	1	0r
		R Ramírez Hidalgo	6	0					R Ramírez Hidalgo	6	6
	WC	Pavel Tsoy	62	1					Y Uchiyama	1	4
		Y Uchiyama	77	6												R Ramírez Hidalgo	6	6
		A Bega	6	7											3	A Weintraub	2	4
		N Barrientos	3	5					A Bega	6	4	2
		C Zampieri	77	2	4			3	A Weintraub	3	6	6
	3	A Weintraub	64	6	6																		R Ramírez Hidalgo	2	77	77
	7	N Milojević	6	5	1																		R Ramanathan	6	65	60
		S Diez	3	7	6				S Diez	5	3
	Q	M Kalovelonis	4	3					R Ramanathan	7	6
		R Ramanathan	6	6												R Ramanathan	6	6
	WC	S Fayziev	4	5											2	R Albot	4	4
		A Karatsev	6	7					A Karatsev	64	7	2
		T-h Yang	63	4				2	R Albot	77	5	6
	2	R Albot	77	6

References

• Main Draw
• Qualifying Draw