Singles
2016 Uruguay Open
Champion	Diego Schwartzman
Runner-up	Rogério Dutra Silva
Score	6–4, 6–1

Guido Pella was the defending champion but chose not to defend his title.

Diego Schwartzman won the title after defeating Rogério Dutra Silva 6–4, 6–1 in the final.

Seeds

Draw

Finals

	Semifinals							Final
		Cristian Garín	2	2
	6	Rogério Dutra Silva	6	6
								6	Rogério Dutra Silva	4	1
								2/WC	Diego Schwartzman	6	6
	5	Carlos Berlocq	1	1r
	2/WC	Diego Schwartzman	6	4

Top half

	First round							Second round							Quarterfinals							Semifinals
	1/WC	N Almagro	77	78
	Q	N Jarry	64	66				1/WC	N Almagro	7	6
		A De Greef	77	6					A De Greef	5	3
	Q	A Molteni	62	3											1/WC	N Almagro	6	5	3
		H Podlipnik	3	6	3											C Garín	3	7	6
		C Garín	6	3	6				C Garín	6	3
	WC	M Felder	0	2				7	G Andreozzi	4	2r
	7	G Andreozzi	6	6																			C Garín	2	2
	3	H Zeballos	6	6																		6	R Dutra Silva	6	6
		E Gómez	4	4				3	H Zeballos	6	3	6
		JI Londero	6	6					JI Londero	2	6	3
		MT Barrios Vera	0	1											3	H Zeballos	6	4	2
		DE Galán	5	7	5										6	R Dutra Silva	2	6	6
		F Mena	7	5	7				F Mena	1	2
	Q	M Linzer	77	2	0r			6	R Dutra Silva	6	6
	6	R Dutra Silva	65	6	2

Bottom half

	First round							Second round							Quarterfinals							Semifinals
	5	C Berlocq	6	6
		Juan Ignacio Galarza	2	2				5	C Berlocq	6	6
		F Coria	6	6					F Coria	1	2
		A Collarini	4	1											5	C Berlocq	3	6	6
		C Zampieri	3	77	6										4	Í Cervantes	6	4	3
		Mariano Kestelboim	6	65	1				C Zampieri	7	2	1
		A Velotti	3	4				4	Í Cervantes	5	6	6
	4	Í Cervantes	6	6																		5	C Berlocq	1	1r
	8	N Kicker	6	6																		2/WC	D Schwartzman	6	4
		K Uchida	2	1				8	N Kicker	6	6
		Bastián Malla	6	6					B Malla	1	1
	WC	S Maresca	3	4											8	N Kicker	4	64
	Q	J Menezes	2	3											2/WC	D Schwartzman	6	77
		T Lipovšek Puches	6	6					T Lipovšek Puches	1	3
		Maximiliano Estévez	0	1				2/WC	D Schwartzman	6	6
	2/WC	D Schwartzman	6	6

References

• Main draw
• Qualifying draw