Singles
2018 Challenger Ciudad de Guayaquil
Champion	Guido Andreozzi
Runner-up	Pedro Sousa
Score	7–5, 1–6, 6–4

Gerald Melzer was the defending champion but lost in the first round to Federico Coria.

Guido Andreozzi won the title after defeating Pedro Sousa 7–5, 1–6, 6–4 in the final.

Seeds

Draw

Finals

	Semifinals							Final
		Arthur De Greef	5	2
		Pedro Sousa	7	6
									Pedro Sousa	5	6	4
								3	Guido Andreozzi	7	1	6
	3	Guido Andreozzi	6	710
	PR	Santiago Giraldo	4	68

Top half

	First round							Second round							Quarterfinals							Semifinals
	1	P Cuevas	6	6
	WC	D Hidalgo	3	0				1	P Cuevas	6	2	6
		G Melzer	2	4				Q	F Coria	4	6	1
	Q	F Coria	6	6											1	P Cuevas	5	3
		DE Galán	4	0												A De Greef	7	6
		A De Greef	6	6					A De Greef	6	6
	WC	J Hernández-Fernández	6	77				WC	J Hernández-Fernández	0	4
	6	T Monteiro	1	62																			A De Greef	5	2
	LL	U Blanch	7	6																			P Sousa	7	6
		F Bagnis	5	4				LL	U Blanch	4	1
		F Argüello	4	6	6				F Argüello	6	6
		G Clezar	6	2	1											F Argüello	66	3
	WC	N Álvarez	4	4												P Sousa	78	6
		P Sousa	6	6					P Sousa	4	6	6
	Q	T Seyboth Wild	6	3	4			7	H Dellien	6	1	4
	7	H Dellien	3	6	6

Bottom half

	First round							Second round							Quarterfinals							Semifinals
	5	P Lorenzi	6	66	77
	Q	M Cuevas	4	78	65			5	P Lorenzi	66	2
		P Krstin	6	77					P Krstin	78	6
		R Cid Subervi	3	63												P Krstin	4	2
	WC	E Gómez	2	6	4										3	G Andreozzi	6	6
		T Bellucci	6	3	6				T Bellucci	3	2
		C Berlocq	66	2				3	G Andreozzi	6	6
	3	G Andreozzi	78	6																		3	G Andreozzi	6	710
	8	JI Londero	6	6																		PR	S Giraldo	4	68
		L Giustino	2	4				8	JI Londero	65	79	6
	Q	JP Varillas	3	6	3				R Quiroz	77	67	1
		R Quiroz	6	3	6										8	JI Londero	7	63	67
	PR	S Giraldo	7	6											PR	S Giraldo	5	77	79
		J Domingues	5	3				PR	S Giraldo	7	7
		G Elias	63	6	1			LL	M Zekić	5	5
	LL	M Zekić	77	0	6

References

• Main Draw
• Qualifying Draw