54321 may refer to:

  • 54321, a 2016 Tamil-language film
  • "5-4-3-2-1", a song by Manfred Mann
  • 5-4-3 rule or 5-4-3-2-1 rule, an Ethernet design guideline
  • Countdown, a sequence of backward counting towards a scheduled event
  • "54321", a 2022 song by Offset
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