ACB may refer to:

People

• Amy Coney Barrett, Associate Justice of the United States Supreme Court
• Ana Clara Benevides, person who died during Taylor Swift concert due to extreme heat

Banking

• African Central Bank, one of the three financial institutions of the African Union
• Asia Commercial Bank, a commercial bank in Vietnam

Organizations

• American Council of the Blind, a nationwide organization in the US
• Anti-Corruption Bureau, Andhra Pradesh, India
• ASEAN Centre for Biodiversity an intergovernmental organization
• Association for Clinical Biochemistry and Laboratory Medicine, the British professional body for clinical biochemists, a member of the Science Council
• Aurora Cannabis, whose stock is publicly traded under the ticker symbol ACB
• Australian Classification Board, Australia's statutory censorship and classification body

Sports

• Afghanistan Cricket Board, the governing body for professional and amateur cricket in Afghanistan
• Asociación de Clubs de Baloncesto, governing body of principal basketball league in Spain
• Absolute Championship Berkut, a mixed martial arts, kickboxing, and Brazilian jiu-jitsu promotion based in Russia
• Liga ACB, the top professional basketball division of the Spanish basketball league system
• Australian Cricket Board, the management for all international and domestic cricket in Australia (the board also manages the Australian Mens and Australian Women's team)

Other uses

• Adjusted cost base, to calculate the cost of an investment for tax purposes
• Airport City Belgrade
• Amphibious Construction Battalion of the US Navy
• Aortocoronary bypass, a medical procedure
• Air circuit breaker
• Acton Bridge railway station, Cheshire, England, National Rail station code
• T Áncá language of Nigeria, which may be the same as the Manta language of Cameroon (ISO 639-3 code acb)
• Antrim County Airport, Bellaire, Michigan, US, IATA code