Amitis or Amytis may refer to:
- Amytis of Babylon (c. 630–565 BCE), daughter of Cyaxares and wife of Nebuchadnezzar
- Amytis of Media (6th century BCE), daughter of Astyages and wife of Cyrus II
- Amytis of Persia (5th century BCE), daughter of Xerxes I
- Amytis Towfighi, American neurologist and professor
- 5560 Amytis, a minor planet
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