Antonio Medina may refer to:
- Antonio Medina y Céspedes (1824-1885), Afro-Cuban poet and playwright
- Antonio Medina Comas (born c. 1969), executive director of the Puerto Rico Industrial Development Company
- Antonio Medina García (1919–2003), Spanish chess master
- Antonio Medina (footballer) (born 1984), Argentine footballer
See also
- José Antonio Medina (born 1996), Mexican footballer
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