Ardizzone is an Italian surname. Notable people with the surname include:
- Edward Ardizzone (1900–1979), English artist, writer and illustrator
- Francesco Ardizzone (born 1992), Italian footballer
- Joseph Ardizzone (1884–1931), American mob boss
- Simon Ardizzone, American documentary film director and producer
- Tony Ardizzone (born 1949), American writer
- Tony Ardizzone (American football), properly Anthony Allen Ardizzone (born 1956), former American football player
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