Asencio is a Spanish surname. Notable people with this name include:
- Asencio, or Henry Asencio (born 1972), American painter
- Diego C. Asencio (1931–2020), American diplomat
- Fabrice Asencio (1966–2016), French footballer
- Jairo Asencio (born 1983), Dominican baseball pitcher
- Miguel Asencio (born 1980), Dominican former baseball pitcher
- Nicolás Asencio (born 1975), Ecuadorian footballer
- Vicente Asencio (1908–1979), Spanish composer
See also
- Asencio River, a river in Chile
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