Avilés is a Spanish surname. Notable people with the surname include:
- Alicia Avilés, educator and community leader in Costa Rica
- Caleb Avilés, former member of the boy band MDO
- Gabriel de Avilés, 2nd Marquis of Avilés (c. 1735 – 1810), governor of Chile, viceroy of Río de la Plata, and viceroy of Peru
- Lucho Avilés (1938–2019), Uruguayan-born Argentine journalist and television presenter
- Luis Avilés (born 1990), Argentine professional footballer
- Óscar Avilés (1924–2014), Peruvian musician
- Pedro Avilés (born 1956), Spanish writer
- Pedro Menéndez de Avilés (1519–1574), first governor of Spanish Florida & governor of colonial Cuba
- Ramón Avilés (1952–2020), Puerto Rican baseball player
- Raúl Avilés (born 1964), Ecuadorian footballer
- René Avilés Fabila (1940–2016), Mexican writer
- Tomás Avilés (born 2004), Argentine professional footballer
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