Hexetidine
Clinical data
Trade namesBactidol, others
AHFS/Drugs.comInternational Drug Names
Pregnancy
category
  • Not to be used by pregnant women
Routes of
administration		Topical (mouthwash)
ATC code
Legal status
Legal status
Identifiers
  • 1,3-bis(2-ethylhexyl)-5-methylhexahydropyrimidin-5-amine
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.005.012
Chemical and physical data
FormulaC21H45N3
Molar mass339.612 g·mol−1
3D model (JSmol)
  • CCCCC(CC)CN1CC(CN(C1)CC(CC)CCCC)(C)C
  • InChI=1S/C22H46N2/c1-7-11-13-20(9-3)15-23-17-22(5,6)18-24(19-23)16-21(10-4)14-12-8-2/h20-21H,7-19H2,1-6H3 ☒N
  • Key:ZSHBZCXOMHHPCE-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Hexetidine is an anti-bacterial and anti-fungal agent commonly used in both veterinary and human medicine. It is a local anesthetic, astringent and deodorant and has antiplaque effects.[1]

Hexetidine is the medicinal ingredient in Sterisol, which is labelled for the symptomatic treatment of: streptococcal pharyngitis ('strep throat'), tonsillitis, pharyngitis, laryngitis, gingivitis, ulcerative stomatitis, oral thrush and Vincent's angina; postoperative hygiene following tonsillectomy, throat or oral surgery. Hexetidine is not the same as Chlorhexidine, another chemical commonly used in mouthwash, or the antimicrobial drug Hexedene (C22H45N3).[2]

In the UK, hexetidine is the active ingredient in the medicated mouthwash branded Oraldene. In Canada, hexetidine was the active ingredient in the medicated mouthwash branded Steri/sol which has been discontinued. It used to be produced by McNeil Consumer Healthcare, a division of Johnson & Johnson (originally Warner–Lambert, then marketed by Pfizer after its acquisition since 2007). Oraldene contains 0.1 g/100 ml of hexetidine. In some European countries, the gargle solution and mouth spray in bottles of 40 ml named Hexoral (by Mcneil) also contains 0.2% hexetidine as its active compound. In Greece it is called Hexalen mouth wash[3] (also available in spray). Hexetidine can also be found in the mouthwash Bactidol (by Mcneil) which is sold in many Asian countries. In Germany, hexetidine vaginal suppositories branded Vagi-Hex are available to be used for vaginal antisepsis. They are also used in late pregnancy for reducing neonatal infectious mortality and morbidity due to group B streptococcal infections;[4] nonetheless, hexetidine is to be used with care during pregnancy, and its vaginal use is counter-indicated in the first three months of pregnancy.[5]

Hexetidine

References

  1. ↑ Kapić E, Becić F, Becić E (2002). "Hexetidine--an oral antiseptic". Med Arh. 56 (1): 43–8. PMID 11917691.
  2. ↑ "Hexedine | CAS No- 5980-31-4 | Simson Pharma Limited".
  3. ↑ "Γαληνός - Σκεύασμα - HEXALEN MOUTH.WASH 0,1% W/V FL x 200 ML (Γυάλινο φιαλίδιο) - Γενικά".
  4. ↑ Weidinger H, Passloer HJ, Kovacs L, Berle B (November 1991). "[The advantage of preventive vaginal antisepsis with hexetidine in obstetrics and gynecology]". Geburtshilfe Frauenheilkd (in German). 51 (11): 929–35. doi:10.1055/s-2008-1026238. PMID 1773929.
  5. ↑ Vagi-Hex: Gegenanzeigen (Vagi-Hex: Counterindications, in German language)
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