Benjamin Holmes may refer to:
- Benjamin Holmes (Canadian politician) (1794–1865), Lower Canada businessman
- Benjamin Holmes (Missouri politician) (1846–1914), Democratic Mayor of Kansas City
- Ben Holmes (baseball) (1858–1949), American baseball player
- Ben Holmes (1890–1943), American film director
- Ben Holmes (American football)
- Benjamin Holmes (death in absentia) (born 1952)
- Ben Wetzler (born "Benjamin Holmes-Wetzler", born 1991), American professional baseball pitcher for the Miami Marlins
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