Big C is a chain of hypermarkets in Thailand and Vietnam.

Big C may also refer to:

• Cancer
• The Big C (TV series)
• "Big C" (fight song), a fight song of the University of California, Berkeley
• The Big "C", a giant concrete block "C" in the Berkeley Hills of California, United States
• Chris Hardwick, Comedian and host of the Nerdist Podcast
• Big Cass, American professional wrestler

BIGC may refer to:

• Bangladesh Institute of Glass and Ceramics, established in 1951
• BigCommerce stock ticker

See also

• Great Big Sea, a Canadian folk-rock band
• Small-C, a subset of the C programming language