Brain Drain may refer to:

• Human capital flight, also known as "brain drain"
• Brain Drain (album), a Ramones album
• Brain Drain (comics), a Marvel Comics character
• "Brain Drain" (Charmed), an episode of the television series Charmed
• Brain Drain (film), 2009 Spanish comedy film directed by Fernando González Molina
• "Brain Drain", an episode of the Disney cartoon series Phineas and Ferb
• "Brain Drain", an episode of the Disney television series The Book of Pooh
• "Brain Drain", an episode of the Marathon Media cartoon series Totally Spies
• "Brain Drain", an episode of the Nickelodeon cartoon series Fanboy & Chum Chum
• "Brain Drain", an episode of the Nickelodeon television series The Penguins of Madagascar
• Brain Drain, the slide filled with soap in Nickelodeon's game show, BrainSurge
• The Brain Drain, a BBC comedy panel show
• Brain Drain, a previously unreleased song by British rock band The Lightning Seeds on 1997 compilation album Like You Do... Best of The Lightning Seeds