Bren is a surname. Notable people with the surname include:
- Donald Bren (born 1932), American businessman
- Frank Bren (born 1943), Australian actor and playwright
- J. Robert Bren (1903 – 1981), Mexican-American filmmaker
- Llywelyn Bren (died 1318), Welsh rebel
- Matevž Bren (born 1954), Slovenian mathematician
- Steve Bren (born 1960), American racing driver
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