Casco is a surname. Notable people with the surname include:
- Agustín Casco (born 1997), Argentine professional footballer
- Gladys Bernarda Casco (born 1954), Honduran politician
- Gonzalo Casco (1533–c.1588), Spanish military leader and conquistador in what is now Paraguay
- Horacio Casco (1886–1931), Argentine fencer who competed in the 1924 Olympics
- Juan Casco (born 1945), Paraguayan retired footballer
- Milton Casco (born 1988), Argentine professional footballer
- Zelmar Casco (1926–2020), Argentine fencer who competed in the 1964 Olympics
See also
- Cascos, another surname
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