Castile or Castille is a surname. Notable people with the surname include:
- Castile:
- Brooke Castile (born 1986), American pairs figure skater
- Christopher Castile (born 1980), American actor
- L. J. Castile (born 1987), American football player
- Philando Castile (1983–2016), American man fatally shot by a police officer in St. Anthony, Minnesota
- Castille:
- Hadley Castille (1933–2012), Cajun fiddler
- Simeon Castille (born 1985), NFL cornerback
See also
- Emilio J. Castilla, Spanish academic
- Javier Castilla (born 1981), Colombian professional squash player
- Vinny Castilla (born 1967), Mexican professional baseball player
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