Cathedral of the Holy Cross or Holy Cross Cathedral may refer to:

Africa

• Cathedral of the Holy Cross, Lagos, the Roman Catholic Cathedral in Lagos, Nigeria
• Cathedral of the Holy Cross, Lusaka, the Anglican cathedral in Lusaka, Zambia

Asia

• Cathedral of the Holy Cross, Gyumri, an Armenian Catholic cathedral in Gyumri, Armenia
• Armenian Cathedral of the Holy Cross, on Akdamar Island in Van Lake, Turkey

Europe

• Cathedral of the Holy Cross and Saint Eulalia, the Roman Catholic cathedral in Barcelona, Catalonia, Spain
• Church of the Holy Cross, Nin, the former Roman Catholic cathedral of Nin, Croatia
• Cathedral Basilica of the Holy Cross, Opole, Poland
• Temple of the Exaltation of the Holy Cross, a Greek Catholic cathedral in Bratislava, Slovakia
• Russian Church, Geneva, a Russian Orthodox cathedral in Geneva, Switzerland
• Greek Catholic Cathedral, Uzhhorod, Ukraine

North America

• Cathedral of the Holy Cross (Boston), the current Roman Catholic cathedral in Boston
• Holy Cross Church, Boston, the first Roman Catholic cathedral in Boston
• Metropolitan Cathedral Church of the Holy Cross, Our Lady of Regla, and St Francis of Assisi, the Roman Catholic cathedral in Chihuahua, Mexico
• Holy Cross Armenian Cathedral (Montebello, California), an Armenian Apostolic Church cathedral
• Holy Cross African Orthodox Pro-Cathedral, New York City
• Holy Cross Cathedral, Loganville, Georgia, the cathedral of the Anglican Diocese of the South

Oceania

• Holy Cross Cathedral, Geraldton, the cathedral of the Anglican Diocese of North West Australia, in Geraldton, Western Australia
• Holy Cross Pro-Cathedral, Vanimo, the pro-cathedral of the Roman Catholic Diocese of Vanimo, Papua New Guinea