Charles Keene may refer to:
- Charles Keene (artist) (1823–1891), English artist and illustrator
- Charles Keene (archer) (1864–1926), British Olympic archer
- Charles Keene (racing driver) (fl. 1914), American racing driver
- Charles Keene (diplomat), United Kingdom chargé d'affaires to Sweden
See also
- Charles Kean (1811–1868), actor
- Charles Keane (disambiguation)
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