Christopoulos (Greek: Χριστόπουλος) is a Greek surname. Notable people with the surname include:

• Anastasios Christopoulos (1805-1887), Greek revolutionary leader
• Athanasios Christopoulos, Greek poet
• Dimitrios Christopoulos, Greek athlete
• George Christopoulos, Australian association football player
• Giannis Christopoulos (born 1972), Greek association football coach
• Spyros Christopoulos, Greek footballer
• Stephanos Christopoulos, Greek wrestler
• Vasileios Christopoulos, Greek writer
• Yannis Christopoulos, Greek basketball coach