Coke is a surname. Notable people with the surname include:

• Coke (footballer) (b. 1987), a Spanish footballer
• Christopher Coke (b. 1969), alleged drug lord in Jamaica
• David Coke (1915–1941), a British pilot during World War II
• Dorothy Coke (1897-1979), a British artist
• Edward Coke (1552–1634), English entrepreneur and jurist
• Edward Coke (1758–1837), a British politician and landowner
• Edward Coke, 7th Earl of Leicester (1936–2015), a British earl
• Giles Coke, an English footballer
• Jānis Čoke (1878–1910), a Latvian revolutionary and bank robber
• John Coke (1563–1644), an English politician
• John Talbot Coke (1841-1912), British Army Major-general and author of a Coke family history
• Peter Coke (1913–2008), a British actor, playwright and artist
• Phil Coke, an American major league baseball pitcher on the Tigers as of 2010-2011
• Richard Coke, an American lawyer, farmer, and statesman
• Richard Coke Jr., a Virginia congressman
• Richard Toby Coke (born 1954), an English politician
• Roger Coke a 17th-century English writer, and son of Henry Coke
• Roger Sacheverell Coke (1912–1972) an English composer and pianist
• Thomas Coke (bishop) (1747–1814), the first Methodist Bishop
• Thomas Coke, 1st Earl of Leicester (seventh creation) (1754–1842), agricultural reformer
• Van Deren Coke (1921-2004), American photographer, scholar and museum professional