Colocolo, colo-colo, Colo-Colo, or Colo Colo may refer to:
- Colocolo (tribal chief), 16th century Mapuche leader and Chilean folk hero.
 - Colo Colo (mythology), evil rat-like creature from Mapuche mythology.
 - Colocolo (Leopardus colocolo), a South American cat native to Chile.
 - Colo-Colo, a football team from Macul, Santiago, Chile.
 - Colo Colo de Futebol e Regatas, a football team from Ilhéus, Bahia, Brazil.
 - Colo-colo (condiment), hot and spicy condiment the cuisine of the Maluku archipelago, Indonesia.
 - Colocolo opossum (Dromiciops gliroides), or monito del monte, a South American marsupial.
 - Qulu Qulu, Hispanicized Colo Colo, an archaeological site in Peru
 - Chilean ship Colo Colo various
 
See also
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