Cosimo de' Medici (1389–1464) was the founder of the Medici family.
Cosimo de' Medici may also refer to:
- Cosimo I de' Medici, Grand Duke of Tuscany (r. 1537–1569)
- Cosimo II de' Medici, Grand Duke of Tuscany (r. 1609–1621)
- Cosimo III de' Medici, Grand Duke of Tuscany (r. 1670–1723)
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