Wraparound story

Unlike the first two Creepshow installments, in which the wraparound element linking the stories was a horror comic, Creepshow 3 takes an approach similar to Quentin Tarantino's Pulp Fiction in which characters from each story interact with each other during the film. There is also a hot dog stand as a common element in the movie. Brochures, ads, and other things from the hot dog stand are peppered throughout.

Alice

Alice Jacobs is a stuck-up, snotty teenager who comes home to find her father meddling with some kind of universal remote. Whenever he presses one of the buttons on the device, the whole family except for Alice changes ethnicity (i.e., the "Color and Hue Settings" button makes her family turn African-American, and the "Subtitles" button makes her family turn Hispanic). During this, Alice gradually mutates into what is supposedly her "true form".

Just when Alice thinks everything is back to normal, her father presses another button, revealing Alice's true form. Her family is absolutely horrified at the sight of Alice. The story ends with Professor Dayton, the mad scientist from down the street, using another remote control to turn Alice into a white rabbit. Notable in this story is the link to Lewis Carroll's Alice's Adventures in Wonderland. Victor, the vampire, makes an appearance in this story.

The Radio

Jerry is a part-time security guard who buys a radio from a homeless street vendor to replace his old one which has stopped working; however, this mysterious new radio is far from ordinary as it can have a conversation with Jerry. Very soon, Jerry is stealing money and murdering people, all at the whim of his new radio.

After escaping with a sex worker who lives in his building, Jerry is told by the radio to kill the sex worker or she will kill him. He refuses and destroys the radio. Right after, the sex worker finds his gun in the car and shoots Jerry, killing him. Moments after she kills him and wipes the gun clean, she is shot in the head. The shooter is revealed to be the pimp living in the same building as Jerry. When the pimp returns to his car, another radio tells him to go and start a new life.

Alice's father Detective Jacobs also appears in this story, investigating the various murders and strange goings-on taking place. The killer call girl, Rachel, also makes an appearance in this story, as well as the pimp and the two boys from "The Professor's Wife".

Call Girl

Rachael, a murderous call girl, receives a request from a shy man named Victor, her newest client. Rachael thinks he will be just another easy victim. When Rachael gets there, scenes of a murdered family with their necks ripped out are flashed on-screen, and there is no evidence of Victor living in the house.

Rachael then chains him to the bed and proceeds to stab him in the chest, places a pillow over his face, and then has a quick shower. She then keeps hearing Victor's voice saying, "You killed me." Rachael removes the pillow and reveals a gruesome creature with a large, toothy mouth. It is then revealed that Victor is an actual vampire. He kills Rachael and hangs her in the room with the house owners whom he's already killed. Blood starts pouring down her neck in a strange way indicating she will become a vampire. The two young men from The Professor's Wife and the pimp from The Radio appear in this segment.

The Professor's Wife

Two former students come to visit Professor Dayton and meet his fiancée Kathy. Having been victims of his practical jokes in the past, they suspect that Kathy is actually a robot, which the professor has supposedly spent the last 20 years working on in his laboratory. She also behaves like a robot and does not eat or drink, which further indicates that she is probably mechanical.

When the professor is out of the house, they decide to dismantle Kathy to see what she looks like on the inside. To their utter horror, they learn that Kathy really was a human being after all and that she was a mail-order bride. The professor later buys an 'advanced' voodoo kit from the homeless street vendor to put Kathy back together in time for the wedding.

Rachael, the killer call girl, makes a brief appearance in this story.

Haunted Dog

A cruel, miserly doctor, Dr. Farwell, is working a 30-day court-ordered sentence at a free clinic, where he is very insolent and rude towards his patients. He even goes as far as to show no sympathy towards a young girl with a brain tumor and mocks an elderly woman who is going blind. One day, he buys a hot dog.

Dr. Farwell accidentally drops it on the ground. He sadistically decides to give the dirty hot dog to a homeless man who has been bothering him for some spare change. The homeless man dies after taking one bite, and he returns to haunt the cruel doctor. The story ends with the doctor having a heart attack from having had too many encounters with his ghostly stalker. Victor from "Call Girl" also appears in this segment, and he seems to be in cahoots with Dr. Farwell. The homeless man can be heard muttering, "Thanks for the good dog" to Dr. Farwell throughout the segment, an allusion to Creepshow 2's "The Hitch-Hiker". The Hispanic woman from "Alice" also makes an appearance in this story.

Epilogue

It is revealed that the street vendor/homeless man got the two radios from Professor Dayton in "The Professor's Wife". After this tale ends, it then shows Professor Dayton at his wedding with his resurrected wife (who is bandaged up from being murdered in "The Professor's Wife") with a huge crowd around them. It shows Professor Dayton and his wife driving off. Alice's mom states that Alice will look so beautiful on her wedding day to which her family agrees as Alice's rabbit form is in the back seat of Professor Dayton's car. The priest asks the husband how Carol is with the response that she's not well at all and still believes that she has a daughter named Alice. It then zooms in on the back of the hot dog guy's head. He turns around, revealing that he was the Creep (resembling the version from Creepshow 2) all along.