The enzyme 2′,3′-cyclic-nucleotide 2'-phosphodiesterase (EC 3.1.4.16) catalyzes the reaction

nucleoside 2′,3′-cyclic phosphate + H₂O ${\displaystyle \rightleftharpoons }$ nucleoside 3′-phosphate

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name is nucleoside-2′,3′-cyclic-phosphate 3'-nucleotidohydrolase. Other names in common use include ribonucleoside 2′,3′-cyclic phosphate diesterase, 2′,3′-cyclic AMP phosphodiesterase, 2′,3′-cyclic nucleotidase, cyclic 2′,3′-nucleotide 2′-phosphodiesterase, cyclic 2′,3′-nucleotide phosphodiesterase, 2′,3′-cyclic nucleoside monophosphate phosphodiesterase, 2′,3′-cyclic AMP 2′-phosphohydrolase, cyclic phosphodiesterase:3′-nucleotidase, 2′,3′-cyclic nucleotide phosphohydrolase, 2′:3′-cyclic phosphodiesterase, and 2′:3′-cyclic nucleotide phosphodiesterase:3'-nucleotidase. This enzyme participates in purine metabolism and pyrimidine metabolism.

References

• Anraku Y (1964). "A new cyclic phosphodiesterase having a 3′-nucleotidase activity from Escherichia coli B. I. purification and some properties of the enzyme". J. Biol. Chem. 239: 3412–9. PMID 14245396.
• Anraku Y (1964). "A new cyclic phosphodiesterase having a 3′-nucleotidase activity from Escherichia coli B. II. Further studies on substrate specificity and mode of action of the enzyme". J. Biol. Chem. 239: 3420–4. PMID 14245397.
• Center MS, Behal FJ (1968). "A cyclic phosphodiesterase with 3′-nucleotidase activity from Proteus mirabilis". J. Biol. Chem. 243 (1): 138–43. PMID 4295113.
• Olafson RW, Drummond GI, Lee JF (1969). "Studies on 2′,3'-cyclic nucleotide-3'-phosphohydrolase from brain". Can. J. Biochem. 47 (10): 961–6. doi:10.1139/o69-151. PMID 4310670.
• Unemoto T, Hayashi M (1969). "Chloride ion as a modifier of 2′,3′-cyclic phosphodiesterase purified from halophilic Vibrio alginolyticus". Biochim. Biophys. Acta. 171 (1): 89–102. doi:10.1016/0005-2744(69)90108-9. PMID 4303200.