Cynisca was the first woman to win at the ancient Olympic Games.
Cynisca may also refer to:
- Cynisca (horse), a Thoroughbred mare racehorse
- Cynisca (lizard), a genus of lizards in the family Amphisbaenidae
- Cynisca (moth), a synonym of the moth genus Siccyna in the family Erebidae
- Cynisca Cycling, a women's road cycling team
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