D'Angelo (also spelt DiAngelo or Di Angelo) is an Italian surname. Notable people with the surname include:

• Adam D'Angelo (b. 1984), American internet entrepreneur
• Andrew D'Angelo (b. 1965), American jazz musician
• Angelo D'Angelo (b. 1985), Italian footballer
• Beverly D'Angelo (b. 1951), American actress
• Carlo D'Angelo (1919–1973), Italian actor
• Charlene (singer), full name Charlene Marilynn D'Angelo (b. 1950), American singer
• Charles D'Angelo (b. 1985), American personal development coach
• Chico d'Ângelo (b. 1953), Brazilian politician
• Ernesto Pérez d'Angelo (1932–2013), Chilean paleontologist
• Eduardo D'Angelo (1939–2015), Uruguayan actor
• Francesco d'Angelo (1446–1488), Italian sculptor
• Frank D'Angelo (b. 1959), Canadian beverage industry entrepreneur
• Gianna D'Angelo (1929–2013), American soprano
• Gianfranco D'Angelo (1936–2021), Italian actor
• Giuseppe D'Angelo, various people
• Héctor D'Angelo, Argentine retired football player and manager
• Ivan D'Angelo (b. 1990/1991), Italian footballer
• Jacopo d'Angelo (1360–1411), Italian humanist
• José D'Angelo (b. 1989), Argentine footballer
• Josephine D'Angelo (1924–2013), American baseball player
• Luca D'Angelo (b. 1971), Italian football manager
• Louis D'Angelo (1888–1958), American bass-baritone
• Mario d'Angelo (b. 1954), French academic
• Matt Di Angelo (b. 1987), British actor
• Mike D'Angelo (b. 1968), American film critic
• Mirella D'Angelo (b. 1956), Italian actress
• Nino D'Angelo (b. 1957), Italian singer
• Sabrina D'Angelo (b. 1993), Canadian soccer player
• Salvo D'Angelo (1909–1989), Italian film producer
• Santo D'Angelo (b. 1995), Italian footballer
• Sebastián D'Angelo (b. 1989), Argentine footballer
• Sharlee D'Angelo (b. 1973), bassist of Swedish melodic death metal band Arch Enemy
• Roberto D'Angelo (b. 1945), Italian canoeist
• Robin DiAngelo (b. 1956), American author
• Victoria Scott D'Angelo, second wife of Chuck Yeager
• Vincenzo D'Angelo (1951–2008), Italian water-polo player