DEFB106A
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesDEFB106A, BD-6, DEFB-6, DEFB106, defensin beta 106A
External IDsHomoloGene: 134659 GeneCards: DEFB106A
Orthologs
SpeciesHumanMouse
Entrez

245909

n/a

Ensembl

ENSG00000186579
ENSG00000285617

n/a

UniProt

Q8N104

n/a

RefSeq (mRNA)

NM_152251

n/a

RefSeq (protein)

NP_689464

n/a

Location (UCSC)Chr 8: 7.83 – 7.83 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Beta-defensin 106 is a protein that in humans is encoded by the DEFB106A gene.[3][4]

Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 106, DEFB106A and DEFB106B, in head-to-head orientation. This gene, DEFB106A, represents the more centromeric copy.[4]

Function

The purified DEFB106 showed antimicrobial activity against Escherichia coli, Candida albicans and Staphylococcus aureus.[5]

References

  1. 1 2 3 ENSG00000285617 GRCh38: Ensembl release 89: ENSG00000186579, ENSG00000285617 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ, Casavant TL, McCray PB Jr (Feb 2002). "Discovery of five conserved beta -defensin gene clusters using a computational search strategy". Proc Natl Acad Sci U S A. 99 (4): 2129–33. Bibcode:2002PNAS...99.2129S. doi:10.1073/pnas.042692699. PMC 122330. PMID 11854508.
  4. 1 2 "Entrez Gene: DEFB106A defensin, beta 106A".
  5. Xin A (Jan 2014). "Soluble fusion expression, characterization and localization of human β-defensin 6..." Mol Med Rep. 9 (1): 149–55. doi:10.3892/mmr.2013.1768. PMID 24189797.

Further reading


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