DLL1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDLL1, DELTA1, DL1, Delta, Delta-like 1, delta like canonical Notch ligand 1, NEDBAS
External IDsOMIM: 606582 MGI: 104659 HomoloGene: 4104 GeneCards: DLL1
Orthologs
SpeciesHumanMouse
Entrez

28514

13388

Ensembl

ENSG00000275555
ENSG00000198719

ENSMUSG00000014773

UniProt

O00548

Q61483

RefSeq (mRNA)

NM_005618

NM_007865
NM_001379042

RefSeq (protein)

NP_005609

NP_031891
NP_001365971

Location (UCSC)Chr 6: 170.28 – 170.31 MbChr 17: 15.59 – 15.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Delta-like protein 1 is a protein that in humans is encoded by the DLL1 gene.[5]

Function

DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication.[5]

Interactions

Delta-like 1 has been shown to interact with NOTCH2[6][7][8]

References

  1. 1 2 3 ENSG00000198719 GRCh38: Ensembl release 89: ENSG00000275555, ENSG00000198719 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000014773 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: DLL1 delta-like 1 (Drosophila)".
  6. Shimizu K, Chiba S, Saito T, Kumano K, Takahashi T, Hirai H (July 2001). "Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation". J. Biol. Chem. 276 (28): 25753–8. doi:10.1074/jbc.M103473200. PMID 11346656.
  7. Blaumueller CM, Qi H, Zagouras P, Artavanis-Tsakonas S (July 1997). "Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane". Cell. 90 (2): 281–91. doi:10.1016/s0092-8674(00)80336-0. PMID 9244302. S2CID 16544864.
  8. Shimizu K, Chiba S, Hosoya N, Kumano K, Saito T, Kurokawa M, Kanda Y, Hamada Y, Hirai H (September 2000). "Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2". Mol. Cell. Biol. 20 (18): 6913–22. doi:10.1128/mcb.20.18.6913-6922.2000. PMC 88767. PMID 10958687.

Further reading


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