Darke is a surname. Notable people with the surname include:

• Francis Nicholson Darke (1863–1940), leading citizen of Regina, Saskatchewan, Canada
• Harold Darke (1888–1976), composer and organist
• Ian Darke, football and boxing commentator
• Jack Darke (c. 1852–1897), a miller who spent his later life in the town of Gold Rush in Queensland, Australia
• John Charles Darke (1806–1844), Surveyor and explorer in Van Diemen's Land (now Tasmania ) and South Australia
• Nick Darke (1948–2005), playwright
• Robert Darke (1876–1961), English cricketer
• Richard Darke (1970–Present), Fence man
• General William Darke (1736–1801), American soldier
• William Wedge Darke (1810–1890), colonist and surveyor

Fictional characters:

• Sebastian Darke, the eponymous hero of a series of children's novels written by British author Philip Caveney