David Henderson may refer to:

Academy

• David Henderson (philosopher) (born 1954), American philosopher
• David Henderson (psychiatrist) (1884–1965), Scottish psychiatrist
• David W. Henderson (1939–2018), American professor of mathematics
• David Willis Wilson Henderson (1903–1968), Scottish microbiologist. Director of MRE, Porton Down

Economics

• David Henderson (economist) (1927–2018), chief economist at the OECD in Paris from 1984 to 1992
• David R. Henderson (born 1950), American economist

Journalism

• David Henderson (broadcaster) (born 1970), Scottish journalist/newsreader working for BBC Scotland
• David Henderson (American journalist), CBS Network News television and radio journalist

Politics

• David B. Henderson (1840–1906), U.S. politician of the 1890s and 1900s
• David Henderson (Canadian politician) (1841–1922), former Canadian Member of Parliament
• David N. Henderson (1921–2004), U.S. Representative from North Carolina

Sport

• David Henderson (footballer) (1868–1933), Scottish football player (Liverpool FC)
• Dave Henderson (1958–2015), former Major League Baseball player
• Dave Henderson (footballer) (born 1960), retired Irish football goalkeeper
• David Henderson (basketball) (born 1964), former Duke Co-Captain and head basketball coach at University of Delaware
• David C. Henderson (born c. 1917), American football player and coach of football and basketball
• Dave Henderson (ice hockey) (born 1952), Canadian-born French ice hockey coach and player

Others

• David Henderson (British Army officer) (1862–1921), senior British Army and, later, RAF officer
• David Ezekiel Henderson (1879–1968), U.S. federal judge
• David Henderson (poet) (born 1942), poet associated with the Umbra workshop and Black Arts Movement
• Davy Henderson (born c. 1962), Scottish musician, The Fire Engines, Win, The Nectarine No. 9
• David Henderson (Christchurch, New Zealand), property developer in New Zealand