David Rose may refer to:
Business
- David Rose (real estate developer) (1892–1986), American real estate developer and philanthropist
- David L. Rose (born 1967), American business executive and scientist at MIT Media Lab
- David S. Rose (born 1957), American technology entrepreneur and angel investor
Entertainment
- David Rose (artist) (1910–2006), American artist
- David Rose (songwriter) (1910–1990), American songwriter, composer, arranger and orchestra leader
- David Rose (producer) (1924–2017), British television producer and editor
- David Rose, American actor and second male lead in British horror-comedy The Headless Ghost (1959)
- David Rose (1931–2004), British actor, brother of actor Clifford Rose
- David Rose (1946–1994), American violinist and songwriter, part of French project Blue Rose, known for the 1982 title Don't you know
Politics
- David Rose (Guyanese politician) (1923–1969), Governor-General of Guyana
- David Rose (UK politician), Northern Irish unionist politician
- David Stuart Rose (1856–1932), mayor of Milwaukee, Wisconsin, US
Sports
- Dave Rose (basketball) (born 1957), head basketball coach at Brigham Young University
- David Rose (rugby) (1931–2021), Scottish rugby union and Great Britain rugby league footballer
- David Rose (club secretary) (born 1940s), football club secretary of Ipswich Town F.C.
Others
- David A. Rose (1906–1995), American lawyer and judge who served in the Massachusetts state courts
- David Rose (journalist) (born 1959), British writer and journalist
- David J. Rose (1922–1985), professor of nuclear engineering
- David Rose (bishop) (1913–1997), American prelate
- David Rose (Schitt's Creek), character on the CBC and Pop TV sitcom Schitt's Creek
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