David Wilkie may refer to:
- David Wilkie (artist) (1785–1841), Scottish painter
- David Wilkie (surgeon) (1882–1938), British surgeon, scientist and philanthropist
- David Wilkie (footballer) (1914–2011), Australian rules footballer
- David Wilkie (swimmer) (born 1954), Scottish swimmer
- David Wilkie (ice hockey) (born 1974), American ice hockey player
- David Wilkie (taxicab driver) (1949–1984), Welsh taxi driver killed during the UK miners' strike of 1984–85
- Adam Purple, American activist and guerrilla gardener born as David Lloyd Wilkie
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