De Agostini is a surname of Italian origin. Notable people with the surname include:
- Alberto Maria de Agostini (1883–1960), Italian missionary, explorer and geographer
- Giovanni Maria de Agostini (1801–1869), lay monk of Italian origin
- Luigi De Agostini (born 1961), Italian footballer
- Doris de Agostini (1958–2020), Swiss skier
- Virginia De Agostini, international figure skating judge
See also
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