De Graff may refer to:
People
- Arthur C. DeGraff (1899–1983), American cardiologist
- Geoffrey de Graff (born 1949), secular name of American monk Ṭhānissaro Bhikkhu
- John I. De Graff (1783-1848), U.S. Representative from New York
- Laurens de Graaf (1653-1704), a Dutch pirate
Places In the United States:
- De Graff, Kansas, an unincorporated place in Butler County, Kansas
- De Graff, Minnesota, a city in Swift County, Minnesota, United States
- De Graff, Ohio, a village located in Logan County, Ohio, United States
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