Destroy All Humans! is an open-world action-adventure video game series.
Destroy All Humans! may also refer to:
- Destroy All Humans! (2005 video game), the first game in the series
- Destroy All Humans! 2 (2006), the second game in the series
- Destroy All Humans! Big Willy Unleashed (2008)
- Destroy All Humans! Path of the Furon (2008)
- Destroy All Humans! (2020 video game), a remake of the first game
- Destroy All Humans! 2: Reprobed (2022), a remake of the second game
- Destroy All Humans, a 2020 studio album by Hittman
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