Desvignes is a French surname. Notable people with the surname include:
- Margot Desvignes
- Peter Hubert Desvignes
- Pierre Desvignes (1764–1827), French composer
- Thomas Desvignes (1812–1868), English entomologist
- Fabrice Desvignes (born 1972), French chef, winner of the 2007 Bocuse d'Or
See also
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