Ryanoids are a class of insecticides which share the same mechanism of action as the alkaloid ryanodine. Ryanodine is a naturally occurring insecticide isolated from Ryania speciosa.

Ryanoids include natural chemicals which are closely related to ryanodine, such as ryanodol and 9,21-didehydroryanodol,[1] and also chemically distinct synthetic compounds such as chlorantraniliprole (Rynaxypyr), flubendiamide, cyantraniliprole, cyclaniliprole, and tetraniliprole (Tetrino), which are called diamide insecticides.[2][3]

Ryanoids exert their insecticidal effect by interacting with ryanodine receptors, a type of calcium channel. This causes loss of muscle function[3] leading to paralysis and death.

References

  1. ↑ Usherwood, P.N.R.; Vais, H. (1995). "Towards the development of ryanoid insecticides with low mammalian toxicity". Toxicology Letters. 82–83: 247–54. doi:10.1016/0378-4274(95)03558-3. PMID 8597061.
  2. ↑ Teixeira, Luís A; Andaloro, John T (2013). "Diamide insecticides: Global efforts to address insect resistance stewardship challenges". Pesticide Biochemistry and Physiology. 106 (3): 76–78. doi:10.1016/j.pestbp.2013.01.010.
  3. 1 2 IRAC International MoA Working Group (March 2020). "IRAC Mode of Action Classification Scheme Version 9.4". Insecticide Resistance Action Committee.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.