Dositheus (/dəˈsɪθiəs/; Greek: Δωσίθεος, Dōsítheos) is a Greek masculine given name, and it may refer to:

• Dositheos (Samaritan) (fl. 1st century), Gnostic
• Dositheus Magister (fl. 4th century), Roman grammarian and jurist
• Dositheus of Constantinople (died after 1191), or Dositheus I of Jerusalem, Greek Orthodox Patriarch
• Dositheos II of Jerusalem (1641–1707), Greek Orthodox Patriarch of Jerusalem 1669–1707
• Dositheus of Tbilisi (died 1795), Georgian Orthodox archbishop
• Dositheus (Ivanchenko) (1884–1984), bishop of the Russian Orthodox Church, bishop of Brooklyn
• Dositej Obradović, Serbian monk, author, and educator.
• Dositej Vasić, metropolitan of Serbian Orthodox Church.
• Dositej II, Archbishop of Ohrid and Macedonia.