Dubos is a French surname. Notable people with the surname include:
- Jean-Baptiste Dubos (1670–1742), French writer
- Jean-François Dubos (born 1945), French businessman
- René Dubos (1901–1982), American scientist
See also
- Charles Du Bos (1882–1939), French essayist and critic
- Marie-Jeanne Renard du Bos (1700 – between 1730 and 1750), French engraver
- Dubois (disambiguation)
- DuBose (disambiguation)
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