NECAB2

NECAB2
Identifiers
Aliases	NECAB2, EFCBP2, N-terminal EF-hand calcium binding protein 2, stip-2
External IDs	OMIM: 618130 MGI: 2152211 HomoloGene: 62200 GeneCards: NECAB2
Gene location (Human)
Chr.	Chromosome 16 (human)
End	84,002,776 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	120,199,379 bp
RNA expression pattern
	Top expressed in
	nucleus accumbens; ; caudate nucleus; ; amygdala; ; putamen; ; cingulate gyrus; ; Brodmann area 9; ; hypothalamus; ; prefrontal cortex; ; entorhinal cortex; ; orbitofrontal cortex;
	Top expressed in
	habenula; ; olfactory tubercle; ; medial geniculate nucleus; ; medial dorsal nucleus; ; subiculum; ; nucleus accumbens; ; globus pallidus; ; superior colliculus; ; superior frontal gyrus; ; dorsomedial hypothalamic nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; protein binding; calcium ion binding; A2A adenosine receptor binding; type 5 metabotropic glutamate receptor binding; identical protein binding;
Cellular component	cytoplasm; plasma membrane; membrane; axon; dendrite; cell projection;
Biological process	positive regulation of adenosine receptor signaling pathway; positive regulation of ERK1 and ERK2 cascade; positive regulation of glutamate receptor signaling pathway; negative regulation of G protein-coupled receptor internalization; positive regulation of protein localization to membrane; regulation of amyloid precursor protein biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	54550
	117148
	ENSG00000103154
	ENSMUSG00000031837
	Q7Z6G3
	Q91ZP9
	NM_019065; NM_001329748; NM_001329749
	NM_054095
	NP_001316677; NP_001316678; NP_061938
	NP_473436
	Wikidata
View/Edit Human	View/Edit Mouse

N-terminal EF-hand calcium-binding protein 2 is a protein that in humans is encoded by the NECAB2 gene.^[5]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000103154 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031837 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Sugita S, Ho A, Sudhof TC (Jun 2002). "NECABs: a family of neuronal Ca(2+)-binding proteins with an unusual domain structure and a restricted expression pattern". Neuroscience. 112 (1): 51–63. doi:10.1016/S0306-4522(02)00063-5. PMID 12044471. S2CID 18740496.
↑ "Entrez Gene: EFCBP2 EF-hand calcium binding protein 2".

Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Bernier G, Vukovich W, Neidhardt L, et al. (2001). "Isolation and characterization of a downstream target of Pax6 in the mammalian retinal primordium". Development. 128 (20): 3987–94. doi:10.1242/dev.128.20.3987. PMID 11641222.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000103154 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031837 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12044471-5] Sugita S, Ho A, Sudhof TC (Jun 2002). "NECABs: a family of neuronal Ca(2+)-binding proteins with an unusual domain structure and a restricted expression pattern". Neuroscience. 112 (1): 51–63. doi:10.1016/S0306-4522(02)00063-5. PMID 12044471. S2CID 18740496.

[entrez-6] "Entrez Gene: EFCBP2 EF-hand calcium binding protein 2".

[1]

[2]

[3]

[4]

[5]

[6]

References

Further reading