EPHB4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesEPHB4, Ephb4, AI042935, Htk, MDK2, Myk1, Tyro11, EPH receptor B4, HTK, MYK1, TYRO11, HFASD, CMAVM2, LMPHM7
External IDsOMIM: 600011 MGI: 104757 HomoloGene: 20939 GeneCards: EPHB4
Orthologs
SpeciesHumanMouse
Entrez

2050

13846

Ensembl

ENSG00000196411

ENSMUSG00000029710

UniProt

P54760

P54761

RefSeq (mRNA)

NM_004444

NM_001159571
NM_010144

RefSeq (protein)

NP_004435

NP_001153043
NP_034274

Location (UCSC)Chr 7: 100.8 – 100.83 MbChr 5: 137.35 – 137.38 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ephrin type-B receptor 4 is a protein that in humans is encoded by the EPHB4 gene.[5][6]

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development.[6][7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000196411 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029710 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Bennett BD, Wang Z, Kuang WJ, Wang A, Groopman JE, Goeddel DV, Scadden DT (Jun 1994). "Cloning and characterization of HTK, a novel transmembrane tyrosine kinase of the EPH subfamily". J Biol Chem. 269 (19): 14211–8. doi:10.1016/S0021-9258(17)36776-5. PMID 8188704.
  6. 1 2 "Entrez Gene: EPHB4 EPH receptor B4".
  7. Gerety SS, Wang HU, Chen ZF, Anderson DJ (1999). "Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development". Mol. Cell. 4 (3): 403–14. doi:10.1016/S1097-2765(00)80342-1. PMID 10518221.

Further reading


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