Eccles is a surname. Notable people with the surname include:
- Ambrose Eccles (died 1809), Irish Shakespearean scholar
- Charlotte O'Conor Eccles (1863–1911), Irish writer
- Clancy Eccles (1940–2005), Jamaican musician
- David Eccles (businessman) (1849–1912), American businessman who became Utah's first multimillionaire
- David Eccles, 1st Viscount Eccles (1904–1999), British Conservative politician
- George S. Eccles (1900–1982), American businessman and philanthropist
- Graham Eccles, rugby league footballer of the 1960s, '70s and '80s for Leeds, and Wakefield Trinity
- Henry Eccles (1670–1742), English composer
- Henry Eccles (cricketer) (1863–1931), English cricketer
- Henry E. Eccles (1898–1986), Rear Admiral in the United States Navy
- James Eccles (1838–1915), English mountaineer and geologist
- J. R. Eccles (1874–1956), English schoolmaster and author
- John Eccles (disambiguation), several people
- Marriner Stoddard Eccles (1890–1977), American economist and banker, former Federal Reserve Chairman
- Mary Eccles, Viscountess Eccles (1912–2003), American book collector and scholar
- Nigel Eccles, Northern Irish technology entrepreneur and business executive
- Solomon Eccles (1618–1683), English musician
- Spencer Eccles (born 1934), financier and philanthropist in Salt Lake City, Utah
- Tony Eccles (born 1970), English darts player
- William Eccles (disambiguation), several people
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