Emmanuelle is a French feminine given name. Notable people with the given name include:
- Emmanuelle Arsan (1932–2005), Thai-French novelist
- Emanuella Carlbeck (1829–1901), Swedish social reformer
- Emmanuelle Charpentier (born 1968), researcher in microbiology, genetics and biochemistry
- Emmanuelle Chriqui (born 1975), Canadian actress
- Emmanuelle Claret (1968–2013), biathlete
- Emmanuelle Gagliardi (born 1976), Swiss tennis player
- Emmanuelle Grey Rossum (born 1986), known as Emmy Rossum, American actress
- Emmanuelle Khanh (1937–2017), French fashion designer and stylist
- Emmanuelle Lambert (born 1975), French writer
- Emmanuelle Proulx, vocalist and guitarist of the Canadian indie pop band Men I Trust
- Emmanuelle Seigner (born 1966), French actress, former fashion model and lead singer of Ultra Orange & Emmanuelle
- Emmanuelle Vaugier (born 1976), Canadian film and television actress
- Sœur Emmanuelle (1908–2008), Belgian and French religious sister
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