Francis Nicholls may refer to:
- Frankie Knuckles (1955–2014), American DJ and record producer
- Francis T. Nicholls (1834–1912), two-term governor of Louisiana
See also
- Francis D. Nichol (1897–1966), Seventh-day Adventist
- Francis Nicolls (disambiguation), including Francis Nichols
- Francis Nicholson (disambiguation)
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