Francisco Vázquez may refer to:
- Francisco Vásquez de Coronado (c. 1510–1554), Spanish conquistador
- Francisco Vázquez Gómez (1860–1933), Mexican personal physician and politician
- Francisco H. Vázquez (born 1949), Mexican-American scholar and public intellectual
- Fran Vázquez (born 1983), Spanish basketball player
- Francisco Vázquez (cyclist) (born 1952), Mexican Olympic cyclist
- Francisco Vázquez Vázquez (born 1946), Spanish politician and ambassador
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