Frank Barnes may refer to:
- Frank Barnes (left-handed pitcher) (1900–1967), American baseball pitcher
- Frank Barnes (right-handed pitcher) (1926–2014), African American baseball pitcher
- Frank Barnes (actor) (1875–?), American actor
- Frank Barnes (politician) (1904–1952), Australian politician
- Frank C. Barnes (1918–1992), American lawyer, author and cartridge designer
See also
- Honey Barnes (1900–1981), American baseball catcher
- Francis Barnes (disambiguation)
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